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Related Concept Videos

Hybrid Zones02:29

Hybrid Zones

21.9K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
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Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

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The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
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Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

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sp3d and sp3d 2 Hybridization
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In-situ Hybridization02:31

In-situ Hybridization

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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IR Absorption Frequency: Hybridization01:21

IR Absorption Frequency: Hybridization

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Hydrocarbons such as alkanes, alkenes, and alkynes show characteristic C–H stretching absorption bands. These IR stretching frequencies depend on the hybridization of the involved carbon atom and can be explained in terms of the s character of each hybridized atomic orbital.
Among the sp, sp2, and sp3 hybridized orbitals, sp orbitals have the maximum s character (50%). Consequently, the electrons are held more closely to the nucleus, resulting in stronger and shorter C–H bonds that...
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Resonance and Hybrid Structures02:16

Resonance and Hybrid Structures

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According to the theory of resonance, if two or more Lewis structures with the same arrangement of atoms can be written for a molecule, ion, or radical, the actual distribution of electrons is an average of that shown by the various Lewis structures.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.
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Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres
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Superparamagnetic hybrid microspheres affecting osteoblasts behaviour.

Tatiana M Fernandes Patrício1, Silvia Panseri1, Monica Montesi1

  • 1Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, RA, Italy.

Materials Science & Engineering. C, Materials for Biological Applications
|January 5, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed biomimetic, superparamagnetic microspheres for bone regeneration. These iron-doped hydroxyapatite and collagen microspheres enhance osteoblast activity and show potential as drug carriers.

Keywords:
Bio-inspired mineralisationBone tissue engineeringCell behaviourHybrid microspheresIons releaseIron-substituted apatite

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Area of Science:

  • Biomaterials Science
  • Biomineralization
  • Tissue Engineering

Background:

  • Developing effective bone substitutes is crucial for regenerative medicine.
  • Existing materials often lack bioactivity or controlled release properties.
  • Biomimetic approaches offer a promising strategy for creating advanced biomaterials.

Purpose of the Study:

  • To create novel biomimetic hybrid microspheres for bone regeneration.
  • To investigate the bioactivity and osteogenic potential of these microspheres.
  • To explore their suitability as magnetically active bone substitutes and drug carriers.

Main Methods:

  • Fabrication of collagen type I-like peptide (RCP) microspheres mineralized with Fe2+/Fe3+ doped hydroxyapatite (RCPFeHA) using a bio-inspired process.
  • Surface functionalization via emulsification with citrate ions for improved bioactivity and dispersion.
  • In vitro biological study assessing osteoblast cell behavior in response to released ions under physiological and inflammatory conditions.

Main Results:

  • Superparamagnetic RCPFeHA microspheres were successfully synthesized with biomimetic surface functionalization.
  • Osteoblast cells exhibited enhanced activity, maintained normal morphology, and showed no damage in the presence of microspheres.
  • Up-regulation of osteogenic markers and increased bio-resorption ability were observed, correlating with released calcium and iron ions.

Conclusions:

  • The developed RCPFeHA microspheres are bioactive, promote osteoblast activity, and are biocompatible.
  • These microspheres demonstrate potential for bone regeneration, acting as magnetically responsive bone substitutes.
  • Their ability to release ions and respond to stimuli suggests applications as drug carriers with smart functionalities.