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Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture
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Engineering a biomimetic integrated scaffold for intervertebral disc replacement.

Lilong Du1, Qiang Yang1, Jiamin Zhang2

  • 1Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin 300211, People's Republic of China.

Materials Science & Engineering. C, Materials for Biological Applications
|January 5, 2019
PubMed
Summary

Engineered a biomimetic composite for intervertebral disc (IVD) repair using aligned fibers and hydrogels. This tissue engineering approach successfully mimicked native IVD structure and function, showing potential for IVD replacement therapy.

Keywords:
Annulus fibrosusIntervertebral discNucleus pulposusTissue engineeringWet spinning

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Intervertebral disc (IVD) damage necessitates advanced tissue engineering solutions.
  • Current strategies struggle to replicate the complex native IVD structure and function.
  • Developing biomimetic constructs combining nucleus pulposus (NP) and annulus fibrosus (AF) is crucial.

Purpose of the Study:

  • To engineer a biomimetic composite mimicking the AF-NP structure of the intervertebral disc.
  • To evaluate the cellular organization, tissue formation, and mechanical properties of the engineered construct.

Main Methods:

  • Fabrication of a composite using circumferentially oriented poly(ε-caprolactone) (PCL) microfibers seeded with AF cells.
  • Encapsulation of NP cells within an alginate hydrogel core to form the AF-NP composite.
  • In vitro assessment of cell distribution and in vivo evaluation after subcutaneous implantation in nude mice.

Main Results:

  • AF cells aligned along PCL microfibers, and NP cells remained within the alginate core, mimicking native IVD.
  • No significant cell migration or mixing between AF and NP regions was observed.
  • Engineered implants demonstrated progressive tissue formation, extracellular matrix deposition, and improved mechanical properties over time.

Conclusions:

  • The engineered biomimetic AF-NP composite successfully replicates key structural and functional aspects of native IVD.
  • The construct shows potential for developing effective IVD replacement therapies.
  • This approach offers a promising strategy for restoring physiological functionality in damaged intervertebral discs.