Altered expression of long non-coding RNA GAS5 in digestive tumors

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Shounan Lu1, Zhilei Su1, Wen Fu1

  • 1Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

Bioscience Reports
|January 5, 2019
PubMed

Insights

The long non-coding RNA growth arrest-specific 5 (GAS5) shows dual roles in digestive system tumors, acting as both a tumor suppressor and promoter. Its genetic variations, like the rs145204276 polymorphism, also influence cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive system cancers pose significant health challenges.
  • Long non-coding RNAs (lncRNAs) are emerging as key players in gene regulation and disease.
  • Growth arrest-specific 5 (GAS5) is a lncRNA increasingly recognized for its role in tumorigenesis.

Purpose of the Study:

  • To explore the multifaceted role of GAS5 in digestive system tumors.
  • To investigate the impact of GAS5 genetic variations on cancer development.
  • To identify novel therapeutic targets for digestive system cancers.

Main Methods:

  • Literature review and analysis of existing studies on GAS5.
  • Examination of the dualistic function of GAS5 as a tumor suppressor and promoter.
  • Investigation of the carcinogenic effects of GAS5 promoter polymorphisms, specifically the 5-bp indel (rs145204276).

Main Results:

  • GAS5 exhibits complex behavior, acting as both a tumor suppressor and a promoter in digestive system cancers.
  • A specific 5-bp indel polymorphism (rs145204276) in the GAS5 promoter region has been linked to carcinogenic effects.
  • Understanding GAS5's function and its genetic variations is crucial for comprehending digestive system tumor development.

Conclusions:

  • GAS5 is a critical lncRNA in digestive system tumorigenesis with context-dependent functions.
  • Genetic variations in GAS5, such as the rs145204276 polymorphism, contribute to cancer risk.
  • Further research into GAS5 and its polymorphisms offers potential for new diagnostic and therapeutic strategies in digestive system oncology.
Keywords:
GSA5digestive system tumorlarge intervening non-coding RNAsingle nucleotide polymorphisms

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