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Published on: May 10, 2024
Histamine and diabetic nephropathy: an up-to-date overview
Alessandro Pini1, Roberta Verta2,3, Cristina Grange3
1Department of Experimental and Clinical Medicine,University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
Abstract:
The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.
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