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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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25-Hydroxyvitamin D Is Associated with Kidney Function: The Dong-gu Study.

Seong-Woo Choi1, Sun-Seog Kweon2,3, Young-Hoon Lee4

  • 1Department of Preventive Medicine, Chosun University Medical School.

Journal of Nutritional Science and Vitaminology
|January 5, 2019
PubMed
Summary

Higher vitamin D levels correlate with lower kidney function and reduced albuminuria in older Koreans. This study explores the complex relationship between 25-hydroxyvitamin D (25(OH)D), estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR).

Keywords:
25-hydroxyvitamin Dalbuminuriaglomerular filtration ratekidney function

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Area of Science:

  • Nephrology and Endocrinology
  • Investigates the interplay between vitamin D metabolism and kidney function markers.

Background:

  • The kidneys are central to vitamin D biosynthesis, yet the precise relationship between vitamin D levels and kidney function remains unclear.
  • Existing research shows no consensus on how vitamin D concentration correlates with renal health.

Purpose of the Study:

  • To determine the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels, estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR).
  • Focuses on participants aged 50 years and older in Korea to understand these relationships in an aging population.

Main Methods:

  • Analysis of data from 9,166 participants in the Dong-gu Study, including overnight fasting blood and urine samples.
  • Measurement of serum 25(OH)D, eGFR, and ACR.
  • Statistical analysis adjusted for relevant covariates, including log-transformed ACR and eGFR.

Main Results:

  • Lower eGFR was significantly associated with increasing 25(OH)D levels, independent of ACR (p<0.001).
  • Lower ACR was significantly associated with increasing 25(OH)D levels, independent of eGFR (p<0.001).
  • These associations were observed in participants aged 50 years and older in Korea.

Conclusions:

  • Increasing 25-hydroxyvitamin D levels are significantly associated with decreased eGFR and ACR in older Korean adults.
  • These findings suggest an independent relationship between vitamin D status and markers of kidney function and damage.