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Updated: Jan 31, 2026

Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid
Published on: April 11, 2019
Development of Pityriasis Amiantacea after Valproic Acid Therapy
Julio A Diaz-Perez1,2, Joel C Joyce3, Thomas L Cibull1
1Department of Pathology, Northshore University Health System, University of Chicago, Chicago, IL, USA.
Abstract:
Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease.
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