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Updated: Jan 31, 2026

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Primary Endodermal Epithelial Cell Culture from the Yolk Sac Membrane of Japanese Quail Embryos
Published on: March 10, 2016
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Primary Gastric Yolk Sac Tumour
Asim Qureshi1, Mansour Al-Moundhri2, Maha Al-Shaibi3
1Department of Pathology, Sultan Qaboos University Hospital, Muscat, Oman.
Sultan Qaboos University Medical Journal
|January 5, 2019
Summary
Primary gastric yolk sac tumors are rare. This case highlights a patient initially diagnosed with adenocarcinoma who was later found to have a gastric yolk sac tumor metastasized to the mesocolon.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary gastric yolk sac tumors are exceptionally rare, often misdiagnosed.
- This report details a unique case initially treated for gastric adenocarcinoma.
Purpose of the Study:
- To present a rare case of primary gastric yolk sac tumor.
- To emphasize diagnostic challenges and successful treatment strategies for this rare entity.
Main Methods:
- Retrospective analysis of patient's previous gastrectomy slides.
- Abdominal computed tomography scan to identify mesenteric mass.
- Immunohistochemical staining for alpha-fetoprotein (AFP) and gastric carcinoma markers.
Main Results:
- Microscopic examination confirmed yolk sac tumor, positive for AFP and negative for epithelial markers.
- Retrospective review of initial slides also indicated yolk sac tumor.
- The tumor was identified as primary gastric yolk sac tumor with mesocolonic metastasis.
Conclusions:
- Gastric yolk sac tumors require careful pathological evaluation, including AFP staining.
- Early diagnosis and appropriate germ cell tumor protocols lead to favorable treatment outcomes.
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