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CD73 expression in normal and pathological human hepatobiliopancreatic tissues

Amedeo Sciarra1, Inês Monteiro1, Christine Ménétrier-Caux2

  • 1Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, rue du Bugnon 25, 1011, Lausanne, Switzerland.

Cancer Immunology, Immunotherapy : CII
|January 5, 2019
PubMed
Abstract

Insights

CD73 is consistently expressed in hepatobiliopancreatic cancers, supporting anti-CD73 therapy. Aberrant CD73 expression correlates with poor prognosis and aids in diagnosing invasive tumors.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • CD73 ectonucleotidase promotes immune tolerance and cancer invasiveness by producing adenosine.
  • Anti-CD73 blockade is a promising cancer immunotherapy strategy.
  • CD73 expression in the human hepatobiliopancreatic system is not well-characterized.

Purpose of the Study:

  • To characterize CD73 expression in normal and neoplastic tissues of the human liver, pancreas, and biliary tract.
  • To investigate the correlation between CD73 expression patterns and clinicopathological features.
  • To evaluate the diagnostic and prognostic implications of CD73 expression.

Main Methods:

  • Immunohistochemistry was used to assess CD73 expression.
  • A variety of non-neoplastic and neoplastic hepatobiliopancreatic conditions were analyzed.
  • Statistical analysis was performed to correlate CD73 expression with differentiation and survival.

Main Results:

  • CD73 expression was observed in normal hepatobiliopancreatic tissues with specific subcellular patterns.
  • All hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) cases showed CD73 expression.
  • Aberrant CD73 expression, higher intensity, and extent were noted in invasive HCC and PDAC, correlating with poor differentiation and reduced overall survival.

Conclusions:

  • Consistent CD73 expression in hepatobiliopancreatic malignancies supports the use of anti-CD73 therapies.
  • Distinct CD73 expression patterns may aid in the diagnostic workup of these cancers.
  • CD73 expression warrants further investigation as a prognostic marker and therapeutic target.
Keywords:
CD73CholangiocarcinomaEcto-5′-nucleotidaseHepatocellular carcinomaImmunohistochemistryPancreatic carcinoma

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