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Published on: September 30, 2020
Symptom hyper-expression in advanced cancer patients with anxiety and depression admitted to an acute
Sebastiano Mercadante1,2, Claudio Adile3, Patrizia Ferrera3
1Main Regional Center for Pain Relief and Palliative/Supportive Care, Via san Lorenzo 312, 90145, Palermo, Italy. terapiadeldolore@lamaddalenanet.it.
Purpose:
The aim of this study was to compare symptom expression in advanced cancer patients with depression and anxiety and in patients with no such symptoms.
Methods:
Secondary analysis of a previous study assessing the role of an acute palliative supportive care unit (APSCU) in a comprehensive cancer center. Patients completed the Edmonton Symptom Assessment System (ESAS) at admission (T0) and 7 days after or at discharge (T7).
Results:
Three hundred-fourteen consecutive cancer patients admitted to the APSCU were surveyed. Eighty-six and 66 patients improved their level of depression and anxiety, respectively (passing from ≥ 4 to 0-3, from T0 to T7), after that palliative care intervention resulted in a significant improvement of the other symptoms. Changes were statistically significant for both symptoms (P < 0.0005). Patients admitted for uncontrolled pain were more likely to be anxious, while patients admitted for other symptoms or end-of-life care were more likely to be depressed. The presence of anxiety and depression (≥ 4/10 on ESAS) was significantly associated with a higher level of symptom expression at admission and at T7 (P < 0.0005). In patients presenting both psychological symptoms, symptom expression was significantly more relevant in comparison with patients not reporting moderate-severe psychological symptoms. Pain and depression were independently associated with anxiety at T0. Variables independently associated with depression at T0 were drowsiness, appetite, and anxiety.
Conclusions:
Psychological symptoms of ESAS concur to hyper-express some symptoms and make symptom control more difficult. A clear association between anxiety and depression exists.
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