Related Experiment Video
Updated: Jan 31, 2026
05:10
Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
12.6K
PPAR and GST polymorphisms may predict changes in intellectual functioning in medulloblastoma survivors
Adeoye Oyefiade1,2, Lauren Erdman3, Anna Goldenberg3
1Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada. ade.oyefiade@sickkids.ca.
Journal of Neuro-Oncology
|January 5, 2019
Summary
Genetic factors, specifically peroxisome proliferator activated receptor (PPAR) gene variations, may influence cognitive outcomes in pediatric medulloblastoma survivors. These PPAR polymorphisms could predict intellectual changes following treatment.
Area of Science:
- Neuroscience
- Genetics
- Pediatric Oncology
Background:
- Pediatric medulloblastoma treatment improves survival but causes long-term deficits.
- Cognitive outcomes in survivors vary significantly, potentially due to genetic factors.
- Peroxisome proliferator activated receptor (PPAR) and glutathione-S-transferase (GST) genes are implicated.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in PPAR and GST genes and cognitive changes in medulloblastoma survivors.
- To identify specific genetic markers influencing intellectual functioning post-treatment.
Main Methods:
- Genotyping of 44 pediatric medulloblastoma survivors using Illumina Human Omni2.5 BeadChip.
- Assessment of 41 SNPs across PPAR and GST genes.
- Machine learning analysis to correlate SNPs with cognitive decline.
Main Results:
- Age at diagnosis, radiation, chemotherapy, and eight PPAR-associated SNPs predicted intellectual functioning.
- PPARα (rs6008197), PPARγ (rs13306747), and PPARδ (rs3734254) showed significant associations with cognitive changes.
- No significant associations were found for GST gene polymorphisms.
Conclusions:
- PPAR gene polymorphisms may serve as predictors for intellectual outcomes in medulloblastoma survivors.
- PPAR agonists show potential for mitigating treatment-related cognitive deficits.
- Further research is warranted to explore therapeutic applications of PPAR agonists.
Related Concept Videos
01:29Intellectual Disability
738
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
738
02:27Predicting Molecular Geometry
45.8K
VSEPR Theory for Determination of Electron Pair Geometries
45.8K
01:05Single Nucleotide Polymorphisms-SNPs
18.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.3K
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
716
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
716
01:07End Point Prediction: Gran Plot
1.2K
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
For potentiometric titration, the Gran plot is created by plotting...
1.2K