Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.8K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.8K
Heating and Cooling Curves02:44

Heating and Cooling Curves

27.8K
When a substance—isolated from its environment—is subjected to heat changes, corresponding changes in temperature and phase of the substance is observed; this is graphically represented by heating and cooling curves.
For instance, the addition of heat raises the temperature of a solid; the amount of heat absorbed depends on the heat capacity of the solid (q = mcsolidΔT). According to thermochemistry, the relation between the amount of heat absorbed or released by a substance, q, and its...
27.8K
Shock Waves01:16

Shock Waves

2.5K
While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
2.5K
Specific Heat01:16

Specific Heat

67.4K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.4K
Quantifying Heat02:46

Quantifying Heat

62.1K
Thermal Energy Microscopically, thermal energy is the kinetic energy associated with the random motion of atoms and molecules. Temperature is a quantitative measure of “hot” or “cold”, which depends on the amount of thermal energy. When the atoms and molecules in an object are moving or vibrating quickly, they have a higher average kinetic energy (KE) (or higher thermal energy), and the object is perceived as “hot”, or it is described as being at a higher temperature. When the...
62.1K
Variability: Analysis01:11

Variability: Analysis

509
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
509

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Polymer-Solvent Interaction on the Swelling of Polymer Matrix Tablets: A Magnetic Resonance Microscopy Study Complemented by Bond Fluctuation Model Simulations.

Polymers·2024
Same author

Influence of tissue desiccation on critical temperature for thermal damage during Er:YAG laser skin treatments.

Lasers in surgery and medicine·2023
Same author

Objective monitoring of laser tattoo removal in human volunteers using an innovative optical technique: A proof of principle.

Lasers in surgery and medicine·2023
Same author

Measurements of hair temperature avalanche effect with alexandrite and Nd:YAG hair removal lasers.

Lasers in surgery and medicine·2022
Same author

An Intermodal Correlation Study among Imaging, Histology, Procedural and Clinical Parameters in Cerebral Thrombi Retrieved from Anterior Circulation Ischemic Stroke Patients.

Journal of clinical medicine·2022
Same author

Comparison of urethral sling surgery and non-ablative vaginal Erbium:YAG laser treatment in 327 patients with stress urinary incontinence: a case-matching analysis.

Lasers in medical science·2021

Related Experiment Video

Updated: Jan 31, 2026

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans
06:01

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans

Published on: July 3, 2020

9.6K

Variable heat shock response model for medical laser procedures.

Matjaž Lukač1, Andrej Lozar2, Tadej Perhavec3

  • 1Institute Jozef Stefan, Jamova 39, 1000, Ljubljana, Slovenia. matjaz.lukac@fotona.com.

Lasers in Medical Science
|January 5, 2019
PubMed
Summary

A new Variable Heat Shock (VHS) model explains tissue response to laser treatments, revealing high-temperature heat shocks can stimulate regeneration without damage. This advances understanding of laser-tissue interactions for improved therapeutic outcomes.

Keywords:
Arrhenius integralEr:YAG laserHeat shock responseLaser resurfacingTissue regeneration

More Related Videos

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects
09:49

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Published on: June 30, 2017

8.2K
Transformation of Plasmid DNA into E. coli Using the Heat Shock Method
07:46

Transformation of Plasmid DNA into E. coli Using the Heat Shock Method

Published on: August 1, 2007

72.1K

Related Experiment Videos

Last Updated: Jan 31, 2026

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans
06:01

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans

Published on: July 3, 2020

9.6K
Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects
09:49

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Published on: June 30, 2017

8.2K
Transformation of Plasmid DNA into E. coli Using the Heat Shock Method
07:46

Transformation of Plasmid DNA into E. coli Using the Heat Shock Method

Published on: August 1, 2007

72.1K

Area of Science:

  • Biophysics
  • Biochemistry
  • Dermatology

Background:

  • The standard Arrhenius relation predicts linear dependence of tissue damage on exposure duration and exponential dependence on temperature.
  • Laser treatments involve extremely short exposure times, leading to higher-than-expected damage threshold temperatures.
  • Existing models do not fully account for these observed deviations in laser-tissue interactions.

Purpose of the Study:

  • To introduce a novel Variable Heat Shock (VHS) response model.
  • To explain the deviation from the single-process Arrhenius relation at short exposure times.
  • To explore the implications of the VHS model for laser-based tissue regeneration.

Main Methods:

  • Development of a novel Variable Heat Shock (VHS) response model.
  • Theoretical exploration of the VHS model using non-ablative laser resurfacing as an example.
  • Analysis of cell viability as a combined effect of two biochemical processes.

Main Results:

  • The VHS model accounts for observed deviations from the Arrhenius relation at short exposure times.
  • High-temperature heat shocks can be generated in superficial epithelium without irreversible damage under specific conditions.
  • The model supports intense heat shock to epithelia as an indirect trigger for tissue regeneration.

Conclusions:

  • The VHS model provides a more accurate framework for understanding laser-tissue interactions at short exposure times.
  • Non-ablative laser resurfacing, such as with Er:YAG lasers, can induce tissue regeneration through indirect heat shock mechanisms.
  • This research offers a new perspective on laser therapies for tissue repair and regeneration.