The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre
O A Bezborodova1, I V Alekseenko2,3, E R Nemtsova4
1Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia. olgabezborodova@yandex.ru.
Abstract:
In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.
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