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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
SEOM clinical guidelines to primary prevention of cancer (2018)
1Servicio de Oncología Médica, Hospital Juan Ramón Jiménez de Huelva, Ronda Exterior Norte, s/n, 21005, Huelva, Spain. juanbayo@yahoo.es.
Abstract:
Cancer is the leading social and healthcare problem of the twenty-first century. The aim of primary prevention is to decrease the incidence of cancer by avoiding the known causes and risk factors. Nevertheless, it has been estimated that cancer diagnoses could be halved through primary prevention measures. A comprehensive review of the scientific evidence regarding the main carcinogens and risk factors and primary prevention recommendations have been put forth based on this evidence. The GRADE scale has been used to classify the grade of evidence. We present the scientific evidence and recommendations for primary prevention of the major modifiable risk factors: smoking, alcohol, diet, obesity, physical activity, occupational and environmental factors, ultraviolet radiation, infections, and socioeconomic factors. Primary prevention is a simple, effective means to lower the incidence of cancer. Preventive measures must be circulated in the fight against cancer.
Insights
Primary cancer prevention can significantly reduce cancer incidence by avoiding known risk factors like smoking and obesity. Implementing these preventive measures is crucial in the global fight against cancer.
Area of Science:
- Oncology
- Public Health
- Preventive Medicine
Background:
- Cancer represents a major global health challenge in the 21st century.
- Primary prevention strategies aim to reduce cancer incidence by mitigating exposure to carcinogens and risk factors.
Purpose of the Study:
- To conduct a comprehensive review of scientific evidence on major carcinogens and risk factors.
- To provide evidence-based recommendations for the primary prevention of cancer.
Main Methods:
- Systematic review of scientific literature on cancer risk factors.
- Utilized the GRADE scale to assess the quality of evidence.
- Synthesized evidence for modifiable risk factors including smoking, alcohol, diet, obesity, physical activity, environmental exposures, UV radiation, infections, and socioeconomic factors.
Main Results:
- Significant evidence supports primary prevention measures in reducing cancer diagnoses.
- Identified key modifiable risk factors contributing to cancer incidence.
- Recommendations are categorized based on the strength of scientific evidence.
Conclusions:
- Primary cancer prevention is an effective and accessible strategy to lower cancer incidence.
- Dissemination of preventive measures is essential for effective cancer control.
- Public health initiatives should prioritize the implementation of evidence-based preventive strategies.
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