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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Advances in the Solid-Phase Synthesis of Pyrimidine Derivatives
1School of Chemical Sciences , Mahatma Gandhi University , Kottayam , Kerala 686560 , India.
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This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS) of differently substituted and fused pyrimidine derivatives. These synthetic strategies are classified on the basis of the different synthetic routes leading to the particular type of pyrimidine heterocycle formed. The Review discusses the application of a variety of polystyrene derived supports for the construction of pyrimidine rings. The effect of microwave heating on the solid-phase synthesis is also addressed in the review.
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