Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Internal Receptors01:31

Internal Receptors

74.6K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.9K
Overview
110.9K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.5K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.5K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

132.0K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
132.0K
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

32.6K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
32.6K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

3.3K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

50 years of the Czech and Slovak Society of Experimental Cardiology - historical background and scientific benefit.

Physiological research·2025
Same author

Heart remodelling affects ECG in rat DOCA/salt model.

Physiological research·2025
Same author

Cecal volvulus - a rare cause of acute abdomen with ileus.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024
Same author

Development of aesthetic surgery in the Czech Republic - the situation before the COVID pandemic, during the pandemic, and expected changes in the practice of aesthetic surgery in the post-COVID period.

Acta chirurgiae plasticae·2024
Same author

Potential impact on mental health in patients with treatment-resistant schizophrenia - clozapine augmentation with long-acting parenteral antipsychotics: a case series.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2024
Same author

Changes in gene expression in pressure ulcers debrided by different approaches - a pilot study.

Physiological research·2024

Related Experiment Video

Updated: Jan 31, 2026

Sigma's Non-specific Protease Activity Assay - Casein as a Substrate
11:37

Sigma's Non-specific Protease Activity Assay - Casein as a Substrate

Published on: September 17, 2008

78.5K

Cardiac sigma receptors - an update.

T Stracina1, M Novakova

  • 1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. majka@med.muni.cz.

Physiological Research
|January 5, 2019
PubMed
Summary

Sigma receptors are ubiquitous proteins involved in protein folding and trafficking. Cardiac sigma 1 receptors play a key role in cardiovascular diseases, offering potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Sigma receptors, first identified over four decades ago, are ubiquitous proteins with diverse functions.
  • At least two subtypes exist, interacting with various protein classes and acting as molecular chaperones.
  • They are involved in protein folding, trafficking between organelles, and regulating protein function.

Purpose of the Study:

  • To highlight the significant role of sigma receptors, particularly sigma receptor type 1, in cardiac function.
  • To explore the involvement of cardiac sigma 1 receptors in cardiovascular pathophysiology.
  • To establish sigma receptors as potential therapeutic targets for cardiovascular diseases.

Main Methods:

  • Review of existing literature on sigma receptor function and distribution.

More Related Videos

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
05:04

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

3.8K
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

9.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Sigma's Non-specific Protease Activity Assay - Casein as a Substrate
11:37

Sigma's Non-specific Protease Activity Assay - Casein as a Substrate

Published on: September 17, 2008

78.5K
In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
05:04

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

3.8K
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

9.4K
  • Analysis of the role of sigma receptor type 1 in cardiac cells.
  • Investigation of sigma receptor involvement in cardiovascular disease mechanisms.

    • Main Results:

    • Sigma receptor type 1 is dominant in the heart.
    • Cardiac sigma 1 receptors regulate endoplasmic reticulum stress response and calcium signaling in cardiomyocytes.
    • These receptors influence voltage-gated ion channel function and are implicated in cardiac hypertrophy and heart failure.

    Conclusions:

    • Sigma receptors are crucial for normal cardiac function.
    • Dysregulation of cardiac sigma 1 receptors contributes to cardiovascular disorders.
    • Targeting sigma receptors presents a promising strategy for treating cardiovascular diseases.