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Updated: Jan 8, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Biosynthesis of bioactive natural products from Basidiomycota
Hsiao-Ching Lin1, Ranuka T Hewage2, Yuan-Chun Lu3
1Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China. hsiaoching@gate.sinica.edu.tw and Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan, Republic of China and Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan, Republic of China.
Abstract:
The Basidiomycota, also called club fungi, comprise a diverse group of fungi. Basidiomycota are strongly related to ecosystem functioning along with human life. These fungi display a wide range of bioactivities, and some are known to produce of deadly toxins or hallucinogens. Some Basidiomycota have be used as medicinal mushrooms for thousands of years. Recently, the biosyntheses of several classes of natural products from Basidiomycota have been reported. Here, we review recent studies on the biosynthetic pathways and enzymes of bioactive natural products from Basidiomycota fungi, with a focus on terpenoids, alkaloids, ribosomally synthesized and post-translationally modified peptides (RiPPs), and polyketides.
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