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Related Experiment Video

Updated: Jan 31, 2026

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
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Mohs Micrographic Surgery: Past, Present, and Future.

Diana K Cohen1, David J Goldberg1,2

  • 1Skin Laser & Surgical Specialists of NY and NJ, Hackensack, New Jersey.

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|January 5, 2019
PubMed
Summary
This summary is machine-generated.

Mohs micrographic surgery (MMS) effectively treats various skin neoplasms, showing superiority over surgical excision for recurrent nonmelanoma skin cancer. Future advancements include integrating imaging and digital technologies for enhanced outcomes.

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Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Mohs micrographic surgery (MMS) is a specialized surgical technique offering complete margin assessment for skin neoplasms.
  • Its widespread adoption accelerated in the 1970s with the advent of the fresh frozen technique.

Purpose of the Study:

  • To comprehensively review the literature on Mohs micrographic surgery (MMS).
  • Focus areas include the historical origins, current evidence supporting its use, and future directions for the technique.

Main Methods:

  • A systematic literature search was performed using PubMed.
  • Articles relevant to Mohs micrographic surgery (MMS) were identified and analyzed.

Main Results:

  • Randomized controlled trials and prospective studies confirm low recurrence rates for nonmelanoma skin cancer (NMSC) treated with MMS.
  • MMS demonstrated a statistically significant higher cure rate compared to surgical excision for recurrent NMSC.
  • Low recurrence rates were also observed for melanoma and melanoma in situ treated with MMS, alongside efficacy in rare cutaneous neoplasms.

Conclusions:

  • Mohs micrographic surgery (MMS) is a highly effective treatment for numerous skin neoplasms.
  • It offers statistically significant advantages over surgical excision for recurrent and high-risk NMSC.
  • The future of MMS will likely involve advancements in noninvasive imaging, immunostaining, and digital technologies.