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A case report of ocular tuberculosis in a patient with membranous nephropathy

Xiaofang Yin1, Haibo Ge1, Ruifen Miao2

  • 1Nanjing Hospital of Chinese Medicine.

Medicine
|January 5, 2019
PubMed
Abstract

Insights

Patients with membranous nephropathy (MN) are at high risk for tuberculosis (TB). This case highlights rare ocular TB presentation in an immunocompromised patient, emphasizing the need for prompt diagnosis and treatment.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Ophthalmology

Background:

  • Membranous nephropathy (MN) is a chronic kidney disease (CKD) that increases the risk of Mycobacterium tuberculosis (MTB) infection, leading to tuberculosis (TB).
  • Immunocompromised states associated with MN can predispose patients to disseminated infections.
  • Tuberculosis can present with diverse clinical manifestations, including rare ocular symptoms.

Observation:

  • A 63-year-old male patient with a history of membranous nephropathy presented with ocular symptoms.
  • Ocular tissue biopsy and positive PCR results from sputum and bronchoalveolar lavage fluid confirmed disseminated tuberculosis.

Findings:

  • The patient received a diagnosis of disseminated tuberculosis.
  • Antituberculous therapy and immunosuppressive therapy were initiated for the patient.

Implications:

  • This case underscores the importance of considering tuberculosis in immunocompromised patients, even with atypical presentations like ocular symptoms.
  • Early recognition and appropriate diagnostic work-up for TB are crucial for effective management in patients with chronic kidney disease and immunosuppression.
  • Awareness among clinicians regarding rare TB manifestations is essential for timely and accurate diagnosis and treatment.

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