Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Observational Studies01:11

Observational Studies

11.0K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.0K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

154
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
154
Case Studies01:22

Case Studies

13.5K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.5K
Absorption of Nutrients01:19

Absorption of Nutrients

4.0K
Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
4.0K
Naturalistic Observations02:30

Naturalistic Observations

17.1K
If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
17.1K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.4K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A combination of ketones and NAD<sup>+</sup> precursor preserves white matter integrity in mild cognitive impairment.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Development of a Potent Engineered Microbial Lipase for the Treatment of Exocrine Pancreatic Insufficiency.

Gastro hep advances·2026
Same author

Inspiratory muscle training in critically ill adults with a tracheostomy: A prospective, single-centre observational study.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses·2026
Same author

How to perform fluid de-escalation in critical care.

Annals of intensive care·2026
Same author

The toddler milk intervention trial (ToMI): A randomized controlled trial on the effect of protein content in young child formula on BMI and growth.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Decoding sex and gender effects on health: evidence from a nationwide cohort.

Biology of sex differences·2026
Same journal

A meta-analysis of the effects of Baduanjin training on the human body temperature based on infrared thermography technology.

Medicine·2026
Same journal

The predictive ability of "TyG_CVAI" for incident stroke in individuals with different glycemic metabolic status: A national cohort study.

Medicine·2026
Same journal

Symptoms and quality of life in gynecological cancer patients after surgery: Application of latent profile and network analysis.

Medicine·2026
Same journal

Massive hemoptysis as the initial presentation of Behçet disease complicated by multisite thromboembolism: A case report.

Medicine·2026
Same journal

Dextromethorphan-bupropion-associated pharmacovigilance signals based on the FAERS database: An observational study.

Medicine·2026
Same journal

Effects of Mulligan sustained natural apophyseal glide mobilizations on pain, mobility, and lumbar-related disability in chronic non-specific low back pain: A systematic review and meta-analysis.

Medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K

Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) - Study protocol for a

Joerg C Schefold1, Anna S Messmer1, Stefanie Wenger1

  • 1Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Medicine
|January 5, 2019
PubMed
Summary
This summary is machine-generated.

This study investigates nutrient patterns in critically ill patients to understand intensive care unit-acquired weakness (ICU-AW). Findings aim to improve nutritional strategies for patients with prolonged ICU stays and sepsis.

More Related Videos

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.5K
Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology
06:57

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Published on: April 6, 2020

6.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K
A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.5K
Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology
06:57

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Published on: April 6, 2020

6.4K

Area of Science:

  • Critical Care Medicine
  • Nutritional Science
  • Metabolic Research

Background:

  • Intensive care unit-acquired weakness (ICU-AW) is a common complication in critically ill patients with prolonged ICU stays.
  • Metabolic abnormalities may underlie ICU-AW, potentially reflected in changing nutrient profiles.

Purpose of the Study:

  • To assess changes in nutrient patterns in blood and urine over time in critically ill patients.
  • To compare these patterns between patients with and without ICU-AW, and between sepsis and CNS injury groups.

Main Methods:

  • Prospective observational trial recruiting 100 critically ill patients (sepsis or CNS injury groups).
  • Comprehensive nutrient analysis of blood and urine using targeted quantitative mass spectrometry.
  • Assessment of muscle tissue, electrophysiology, body composition, and clinical status.

Main Results:

  • Nutrient patterns in blood and urine will be analyzed over time.
  • Differences in nutrient profiles will be investigated in relation to ICU-AW and sepsis status.

Conclusions:

  • The study aims to elucidate metabolic changes associated with ICU-AW and critical illness.
  • Findings may inform future therapeutic and nutritional interventions for critically ill patients.