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Models of Bone Metastasis
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Bone phosphorus retention and bone development of broilers at different ages.

Yuxin Shao1, Guangming Sun1,2,3,4, Sumei Cao1

  • 1Mineral Nutrition Research Division, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.

Poultry Science
|January 5, 2019
PubMed
Summary
This summary is machine-generated.

Broiler bone development is linked to phosphorus retention, with bone mineral content, density, and strength increasing with age. Phosphorus accumulation and bone development appear to be regulated by bone alkaline phosphatase (ALP) and bone gamma-carboxyglutamate protein (BGP).

Keywords:
agebone developmentbone phosphorus retentionbroiler

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Area of Science:

  • Animal Science
  • Nutritional Physiology
  • Poultry Science

Background:

  • Phosphorus (P) is a critical mineral for bone development and metabolic processes in broilers.
  • Understanding phosphorus retention and its relationship with bone development is essential for optimizing broiler nutrition and health.
  • Age-related changes in bone metabolism and mineral accumulation require detailed investigation.

Purpose of the Study:

  • To investigate tibia phosphorus (P) retention and bone development in broilers from 1 to 42 days of age.
  • To explore the correlations between P retention, bone development parameters, and key bone metabolic markers.
  • To elucidate the potential mechanisms involving bone alkaline phosphatase (ALP) and bone gamma-carboxyglutamate protein (BGP) in broiler bone development.

Main Methods:

  • A total of 320 Arbor Acres male broilers were raised for 42 days on a standard corn-soybean diet.
  • Plasma and tibia samples were collected at seven different time points (0, 7, 14, 21, 28, 35, and 42 days).
  • Measurements included tibia ash P content, total P accumulation, bone mineral content (BMC), bone mineral density (BMD), breaking strength, alkaline phosphatase (ALP), and bone gamma-carboxyglutamate protein (BGP).

Main Results:

  • Tibia ash P content and total P accumulation increased linearly and quadratically with age.
  • Bone development indicators (BMC, BMD, ash content, breaking strength) showed significant linear and quadratic increases with age.
  • Tibia P content correlated positively with BMD, ash, and ALP, while negatively with BGP. ALP positively correlated with ash, and BGP negatively correlated with BMC, breaking strength, and ash content.

Conclusions:

  • Bone P retention is integral to broiler bone development from 1 to 42 days of age.
  • The findings suggest that bone ALP and BGP play regulatory roles in the P retention and bone development process.
  • This study provides insights into the complex interplay of phosphorus metabolism and bone maturation in growing broilers.