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Aspirin treatment does not increase microhemorrhage size in young or aged mice

Sandy Chan1, Morgan Brophy1, Nozomi Nishimura1

  • 1Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America.

Plos One
|January 5, 2019
PubMed

Insights

Aspirin does not increase the size of brain microhemorrhages in aging mice. This study suggests aspirin is safe for use in older individuals, even with potential bleeding risks.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Microhemorrhages are common in aging brains and linked to cognitive decline and neurodegenerative diseases like Alzheimer's.
  • Chronic aspirin use is prevalent in older adults, reducing risks of stroke and heart attack.
  • Concerns exist that aspirin may worsen brain bleeds by prolonging hemorrhage size.

Purpose of the Study:

  • To investigate the effect of aspirin on cortical microhemorrhage size in young and aged mice.
  • To compare aspirin's impact on bleeding with other anticoagulants like heparin.

Main Methods:

  • Femtosecond laser ablation was used to induce controlled microhemorrhages in mouse arterioles.
  • Red blood cell and plasma penetration were measured in young and aged mice, with and without aspirin treatment.
  • Aspirin dosage was administered via drinking water; heparin was given intravenously.

Main Results:

  • Aspirin treatment did not significantly alter microhemorrhage size in either young or aged mice compared to controls.
  • The average hematoma diameter was similar across control, aspirin-treated young, and aspirin-treated aged mice.
  • In contrast, heparin treatment led to a significant increase in hematoma diameter.

Conclusions:

  • Aspirin does not exacerbate bleeding from cortical microhemorrhages.
  • These findings support the safety of chronic aspirin therapy in older individuals regarding brain microhemorrhage size.
  • Aspirin's safety profile appears favorable compared to other anticoagulants like heparin in this context.

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