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Curcumin as a therapeutic agent in leukemia.
Hamideh Kouhpeikar1, Alexandra E Butler2, Faeze Bamian1
1Department of Hematology and Blood Bank, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
Journal of Cellular Physiology
|January 5, 2019
Summary
Curcumin shows promise in treating leukemia, a common childhood cancer with poor outcomes. This review explores curcumin
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Leukemia is a significant cause of cancer-related mortality, particularly in children.
- Conventional chemotherapy for leukemia has limitations, including low efficacy and high relapse rates.
- Curcumin, a compound from turmeric, possesses broad pharmacological properties, including anticancer effects.
Purpose of the Study:
- To review the anticancer effects of curcumin on various types of leukemia.
- To elucidate the mechanisms by which curcumin exerts its anti-leukemic actions.
Main Methods:
- Literature review of cellular and experimental studies.
- Analysis of curcumin's pharmacological actions and anti-leukemic mechanisms.
Main Results:
- Curcumin demonstrates diverse anticancer mechanisms relevant to leukemia treatment.
- Preclinical studies suggest curcumin's efficacy across different leukemia subtypes.
Conclusions:
- Curcumin presents a potential therapeutic agent for leukemia.
- Further research into curcumin's mechanisms could lead to improved leukemia therapies.
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