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Molecular evidence of role of vitamin D deficiency in various extraskeletal diseases

Abolfazl Zendehdel1, Mohammad Arefi2

  • 1Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Cellular Biochemistry
|January 5, 2019
PubMed
Abstract

Insights

Vitamin D impacts more than just bones, influencing immune and endocrine functions. Its receptor (VDR) is widespread, highlighting vitamin D

Area of Science:

  • Endocrinology
  • Immunology
  • Molecular Biology

Background:

  • Vitamin D's role extends beyond skeletal health, affecting multiple bodily systems.
  • Key systems influenced include the immune, endocrine, and cardiopulmonary systems.

Purpose of the Study:

  • To review the molecular evidence linking vitamin D to extraskeletal functions.
  • To highlight the broad physiological impact of vitamin D.

Main Methods:

  • System-wide expression of the vitamin D receptor (VDR) was examined.
  • The endocrinal effects of calcitriol and vitamin D's role in immune responses were analyzed.

Main Results:

  • Widespread VDR expression confirms vitamin D's systemic influence.
  • Vitamin D demonstrates immunoregulatory and hormonal effects.
  • Vitamin D deficiency is linked to various pathologies.

Conclusions:

  • Molecular evidence supports a significant relationship between vitamin D and extraskeletal systems.
  • Vitamin D is crucial for maintaining overall physiological balance.
Keywords:
25(OH)Dcalcitriolextra skeletal manifestationsimmune responsevitamin Dvitamin D receptor

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