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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
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Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

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[Clinico-Pathological Progress in Diabetic Nephropathy].

Takashi Wada

    Rinsho Byori. the Japanese Journal of Clinical Pathology
    |January 5, 2019
    PubMed
    Summary

    Diabetic nephropathy, a leading cause of kidney failure, requires better diagnostic tools. Recent advancements show potential for disease remission, improving patient prognosis for renal and cardiovascular events.

    Area of Science:

    • Nephrology
    • Diabetology
    • Biomarker Discovery

    Background:

    • Diabetic nephropathy is a primary driver of renal replacement therapy globally.
    • Accurate clinico-pathological parameters and biomarkers are crucial for diagnosis and prognosis.
    • Current Japanese classification (2014) grades patients by estimated glomerular filtration rate and albuminuria.

    Purpose of the Study:

    • To review the current understanding and classification of diabetic nephropathy.
    • To highlight the need for improved diagnostic and prognostic tools in laboratory medicine.
    • To explore the implications of diabetic nephropathy remission/regression on patient outcomes.

    Main Methods:

    • Literature review of recent advancements in diabetic nephropathy research.

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  • Analysis of the revised Classification of Diabetic Nephropathy 2014.
  • Examination of clinico-pathological characteristics and biomarkers.

    • Main Results:

    • Diabetic nephropathy necessitates improved diagnostic and prognostic strategies.
    • The 2014 classification provides a framework for assessing disease severity.
    • Emerging evidence suggests diabetic nephropathy remission/regression is linked to better cardiovascular and renal outcomes.

    Conclusions:

    • Further research into laboratory medicine is needed for early and specific diagnosis of diabetic nephropathy.
    • Understanding clinico-pathological characteristics is vital for predicting renal and cardiovascular outcomes.
    • Identifying factors for remission and regression can improve patient prognosis.