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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Hybrid core-shell scaffolds for bone tissue engineering.

Muna M Kareem1, Tom Hodgkinson, Manuel Salmeron Sanchez

  • 1Biomedical Engineering Division, School of Engineering, University of Glasgow, University Avenue, Glasgow, G12 8QQ, United Kingdom.

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|January 5, 2019
PubMed
Summary
This summary is machine-generated.

Hydroxyapatite (HA) in the shell of coaxial electrospun scaffolds enhances bone tissue engineering. These polycaprolactone-polylactic acid/HA scaffolds support cell growth and differentiation, showing potential for bone regeneration.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Coaxial electrospinning offers enhanced functionality over basic electrospinning for tissue engineering.
  • Previous core-shell scaffold designs placed active elements internally; this study investigated shell incorporation for improved surface interactions.
  • Hydroxyapatite (HA) was incorporated into the shell of polycaprolactone (PCL)-polylactic acid (PLA) scaffolds to enhance bioactivity.

Purpose of the Study:

  • To develop and characterize coaxial electrospun PCL-PLA/HA scaffolds for bone tissue engineering.
  • To evaluate the impact of collector type (plate vs. rotating needle) on scaffold morphology and properties.
  • To assess the effect of HA incorporation on scaffold bioactivity, mechanical integrity, and cellular response.

Main Methods:

  • Coaxial electrospinning was used to produce 2D sheets and 3D tubular scaffolds with PCL-PLA core and HA-containing shell.
  • Scaffolds were characterized for fibre diameter, alignment, and mechanical properties using different collectors.
  • Bioactivity was assessed via apatite formation in simulated body fluid (SBF), and cellular behavior (MSCs proliferation and differentiation) was evaluated.

Main Results:

  • Rotating needle collector improved fibre alignment without significantly altering diameter; HA incorporation increased non-uniformity.
  • PCL-PLA/HA scaffolds demonstrated significantly higher bioactivity and apatite formation compared to PCL-PLA scaffolds.
  • Scaffolds maintained structural integrity over 12 weeks of degradation in PBS or SBF, showing sustained BMP-2 release and supporting MSCs growth.

Conclusions:

  • Coaxial electrospinning with HA in the shell is a promising strategy for bone tissue engineering scaffolds.
  • The developed scaffolds exhibit enhanced bioactivity and support cell functions crucial for bone regeneration.
  • These PCL-PLA/HA scaffolds offer potential for clinical applications in bone defect repair.