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Hansenula anomala fungemia.

E Haron1, E Anaissie, F Dumphy

  • 1Department of Medical Specialties, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston 77030.

Reviews of Infectious Diseases
|November 1, 1988
PubMed
Summary

Hansenula fungi rarely cause human infections, but can lead to serious illness in immunocompromised patients. Amphotericin B is the recommended treatment for Hansenula infections.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Fungi in the genus Hansenula are infrequently identified as human pathogens.
  • This study investigates Hansenula species as a cause of human infection.

Observation:

  • A case of catheter-related Hansenula anomala fungemia in an acute leukemia patient is presented.
  • Clinical data from 11 additional patients with Hansenula infections were reviewed.
  • Disease spectrum ranges from asymptomatic fungemia to disseminated infections.

Findings:

  • Key predisposing factors include immunosuppression, intravenous device use, and prior antibacterial therapy.
  • Hansenula infections can present with varying severity, from mild to life-threatening.
  • Limited in vitro data and clinical experience suggest treatment options.

Implications:

  • Hansenula species represent an emerging opportunistic pathogen in susceptible individuals.
  • Early recognition and appropriate antifungal therapy are crucial for patient outcomes.
  • Amphotericin B is identified as the primary treatment for Hansenula infections.

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