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Mongoose rabies.

C O Everard1, J D Everard

  • 1Medical Research Council, Leptospira Laboratory, Bridgetown, Barbados.

Reviews of Infectious Diseases
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Mongooses are significant rabies reservoirs in Africa and Asia. Natural immunity in mongooses is lifelong, influencing rabies epidemiology, and vaccination shows promise for disease control.

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Area of Science:

  • Veterinary science
  • Infectious disease epidemiology
  • Wildlife ecology

Background:

  • Mongooses, indigenous to Africa and Asia, are established in various regions globally.
  • They serve as a primary reservoir and vector for rabies in several locations, including Cuba, Puerto Rico, Grenada, and South Africa.
  • The role of mongooses in rabies transmission can be underestimated, potentially masked by canine rabies cases.

Purpose of the Study:

  • To investigate the epidemiology of rabies in mongoose populations.
  • To assess the prevalence of natural immunity to rabies in mongooses.
  • To evaluate the potential of vaccination for rabies control in mongooses.

Main Methods:

  • Serological surveys to detect rabies virus neutralizing antibodies in mongoose populations.

Related Experiment Videos

  • Analysis of the relationship between antibody-positive and virus-positive mongooses.
  • Immunological response assessment following experimental inoculation with a modified rabies vaccine (Evelyn-Rokitnicki-Abelseth).

    • Main Results:

    • In Grenada, rabies antibodies were detected in nearly 30% of mongooses over a 4-year period, exceeding 50% in some areas.
    • A significant inverse relationship was observed between the annual proportion of antibody-positive and virus-positive mongooses.
    • Natural immunity in mongooses appears to be long-lasting and plays a crucial role in rabies epizootiology.
    • Experimental vaccination with the ERA vaccine elicited a robust immune response.

    Conclusions:

    • Natural immunity is a key factor in mongoose rabies epizootiology, differing from patterns seen in foxes.
    • Rabies vaccination of mongooses holds potential for field application.
    • Further research is needed to understand the impact of wildlife vaccination on populations with high natural immunity before widespread implementation.