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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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Nerves
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy.

R Ganugula1, M Deng2, M Arora1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy , Texas A&M University , Reynolds Medical Building, TAMU Mail Stop 1114 , College Station , Texas 77843 , United States.

ACS Chemical Neuroscience
|January 6, 2019
PubMed
Summary
This summary is machine-generated.

Nanoparticle-encapsulated paclitaxel (nPTX) significantly reduces chemotherapy-induced peripheral neuropathy in rats compared to traditional paclitaxel (PTX) dosing. This improved safety profile supports the use of nPTX in metronomic chemotherapy regimens.

Keywords:
Dorsal root ganglionmotor neuronsnanoparticlesnecrosisneuropathic painpaclitaxelsustained release

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Oncology

Background:

  • Paclitaxel (PTX) is a vital chemotherapy drug, but its use is limited by severe peripheral neuropathy.
  • Metronomic dosing of PTX offers potential benefits but faces challenges due to toxicity and patient compliance.
  • Nanoparticle drug delivery systems show promise for improving therapeutic outcomes.

Purpose of the Study:

  • To evaluate the efficacy of nanoparticle-encapsulated paclitaxel (nPTX) in mitigating PTX-induced peripheral neuropathy.
  • To assess the impact of nPTX on neuropathic pain and neuronal damage in a rat model.

Main Methods:

  • Rats received intraperitoneal injections of PTX or nPTX (2 mg/kg) on alternate days.
  • Neuropathic pain was assessed via behavioral tests measuring tactile and nociceptive thresholds.
  • Neuronal damage was evaluated using histology, immunohistochemistry, and immunofluorescence staining of spinal cord, dorsal root ganglia (DRG), and sciatic nerves.

Main Results:

  • nPTX treatment resulted in significantly less reduction in tactile and nociceptive thresholds compared to PTX.
  • Histological analysis revealed reduced dorsal root ganglion degeneration and motor neuron loss in nPTX-treated rats.
  • Immunofluorescence showed increased neuronal markers (β-tubulin-III, high molecular weight neurofilament) and reduced cell death (TUNEL) in nPTX group.

Conclusions:

  • Nanoparticle encapsulation of paclitaxel (nPTX) effectively alleviates chemotherapy-induced peripheral neuropathy in a preclinical model.
  • nPTX demonstrates a superior risk-benefit profile compared to conventional PTX, potentially enabling safer metronomic chemotherapy.
  • These findings support the development of nPTX for improved cancer treatment strategies.