Related Experiment Video

Updated: Jan 31, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.5K

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets

Kaipeng Xie1, Chenyang Fu2, Suli Wang2

  • 1The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. kaipengxie@njmu.edu.cn.

Journal of Ovarian Research
|January 6, 2019
PubMed

Insights

New cancer-testis antigens (CTAs) show promise for ovarian cancer diagnosis and treatment. These tumor-specific molecules could improve early detection and serve as targets for novel immunotherapies, addressing current challenges in managing this fatal malignancy.

Area of Science:

  • Gynecologic Oncology
  • Cancer Immunology
  • Biomarker Discovery

Background:

  • Ovarian cancer is a leading cause of cancer death globally, often diagnosed late and prone to recurrence and drug resistance.
  • Existing diagnostic and therapeutic tools for ovarian cancer require improvement in sensitivity and specificity.
  • Cancer-testis antigens (CTAs) are promising candidates due to their restricted expression in normal tissues and aberrant presence in various cancers, including ovarian cancer.

Purpose of the Study:

  • To review the expression patterns of candidate CTAs in ovarian cancer.
  • To evaluate the clinical significance of CTAs as biomarkers for ovarian cancer.
  • To explore the potential of CTAs in ovarian cancer immunotherapy.

Main Methods:

  • Literature review of studies identifying and characterizing novel CTAs.
  • Analysis of high-throughput sequencing data for CTA expression in ovarian cancer.
  • Examination of research on CTA roles in ovarian cancer progression and treatment resistance.

Main Results:

  • Aberrant expression of CTAs is linked to ovarian cancer initiation and progression.
  • Some CTAs correlate with clinical outcomes and chemotherapy resistance in ovarian cancer patients.
  • CTAs are immunogenic, suggesting their potential as targets for antigen-specific immunotherapy.

Conclusions:

  • Candidate CTAs represent valuable biomarkers for ovarian cancer diagnosis and prognosis.
  • Understanding CTA mechanisms can reveal new therapeutic strategies.
  • CTAs hold significant potential for developing effective ovarian cancer immunotherapies.
Keywords:
Cancer-testis antigensImmunotherapyOvarian cancerTumor development

More Related Videos

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

15.3K
Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis11:51

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

6.3K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.1K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.0K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.9K