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Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia

Steven M Markwell1, Amanda G Ammer1, Erik T Interval2

  • 1Program in Cancer Cell Biology, Department of Biochemistry, West Virginia University, Morgantown, West Virginia.

Molecular Cancer Research : MCR
|January 6, 2019
PubMed
Summary

Casein kinase 2 alpha (CK2α) phosphorylates cortactin, inhibiting its binding to the Arp2/3 complex. This discovery reveals a new pathway to target cancer cell invasion, particularly in head and neck squamous cell carcinoma (HNSCC).

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