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TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study

Peng Liu1, Zhenjian Zhuo2, Wenya Li3

  • 1Department of Pediatric Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

Bioscience Reports
|January 6, 2019
PubMed

Insights

The TP53 rs1042522 C>G polymorphism, a variant in a tumor-suppressing gene, was investigated for its role in childhood Wilms tumor risk. This study found no significant association between this specific TP53 gene variant and Wilms tumor development in Chinese children.

Area of Science:

  • Genetics
  • Pediatric Oncology
  • Molecular Biology

Background:

  • Wilms tumor is the most frequent kidney cancer in children.
  • The TP53 gene acts as a tumor suppressor by regulating cell growth.
  • The TP53 rs1042522 C>G (Arg72Pro) polymorphism is studied in various cancers, but its role in Wilms tumor is unclear.

Purpose of the Study:

  • To investigate the association between the TP53 rs1042522 C>G polymorphism and the risk of Wilms tumor in Chinese children.
  • To determine if this specific genetic variation contributes to the development of Wilms tumor.

Main Methods:

  • Genotyping of the TP53 rs1042522 C>G polymorphism in 355 Wilms tumor cases and 1070 controls from four Chinese centers.
  • Analysis of the polymorphism's effect on Wilms tumor prevalence using logistic regression models.
  • Stratification analysis to explore potential subgroup associations.

Main Results:

  • No significant relationship was detected between the TP53 rs1042522 C>G polymorphism and the risk of Wilms tumor.
  • Further stratification analyses also failed to reveal any significant associations.
  • The study did not find evidence supporting the TP53 rs1042522 C>G polymorphism as a risk factor for Wilms tumor in this cohort.

Conclusions:

  • The TP53 rs1042522 C>G polymorphism does not appear to significantly impact the risk of developing Wilms tumor in Chinese children.
  • Larger validation studies are needed to definitively establish the role, if any, of this TP53 variant in Wilms tumor susceptibility.
  • Current findings suggest this polymorphism may not be a major genetic contributor to Wilms tumor.

Keywords:
TP53Wilms tumorpolymorphismrs1042522 C>Gsusceptibility

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