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Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

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Published on: September 21, 2012

Mucinous appendiceal neoplasms: classification, imaging, and HIPEC.

David J Bartlett¹, Paul G Thacker¹, Travis E Grotz²

¹Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Abdominal Radiology (New York)

|January 6, 2019

Summary

This summary is machine-generated.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) show promise for peritoneal carcinomatosis from mucinous appendiceal neoplasms (MAN). This review details MAN classification, imaging, and the radiologist

Keywords:

Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy, HIPEC Mucinous appendiceal neoplasm, MAN Pseudomyxoma peritonei, PMP

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Published on: June 20, 2025

Area of Science:

Gastroenterology
Surgical Oncology
Radiology

Background:

Peritoneal carcinomatosis from mucinous appendiceal neoplasms (MAN) presents treatment challenges.
Traditional systemic chemotherapy has limitations for MAN.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) represent advanced therapeutic options.

Purpose of the Study:

To provide a comprehensive review of mucinous appendiceal neoplasms (MAN).
To summarize current understanding of MAN diagnosis and treatment.
To highlight the radiologist's role in managing MAN.

Main Methods:

Literature review of histologic classification of MAN.
Review of imaging findings for mucoceles and pseudomyxoma peritonei.
Description of the radiologist's contribution to patient selection for CRS/HIPEC.

Main Results:

CRS/HIPEC offers advantages over systemic chemotherapy for MAN.
Accurate histologic classification is crucial for treatment planning.
Radiologic assessment aids in disease quantification and patient selection for surgery.

Conclusions:

CRS/HIPEC is a viable and advantageous treatment for MAN.
Radiologists play a key role in the multidisciplinary management of MAN.
Multidisciplinary collaboration improves outcomes for patients with MAN.