Drug-Phospholipid Complex-a Go Through Strategy for Enhanced Oral Bioavailability

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Oral drug delivery is preferred for patient compliance but faces challenges from the gastrointestinal tract's environment.
• Poor aqueous solubility and low permeability significantly reduce drug bioavailability via the oral route.

Purpose of the Study:

• To review the fundamental principles and mechanisms of drug-phospholipid complexes in enhancing oral drug bioavailability.
• To compile formulation strategies, preparation methods, and characterization techniques for these complexes.

Main Methods:

• Literature review focusing on phospholipids and their role in drug absorption.
• Compilation of formulation aspects, preparation techniques, and physical/in silico characterization methods for drug-phospholipid complexes.

Main Results:

• Drug-phospholipid complexes mimic natural nutrient absorption pathways in the gastrointestinal tract.
• These complexes act as solubilizers, emulsifiers, and matrix excipients for poorly soluble and permeable drugs.

Conclusions:

• Drug-phospholipid complexation is a vital strategy for improving oral bioavailability.
• The biodegradable and non-toxic nature of these complexes makes them ideal for oral drug formulations.