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Updated: Jan 31, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Published on: April 11, 2018
Sex differences in ACL loading and strain during typical athletic movements: a musculoskeletal simulation analysis
Jonathan Sinclair1, Darrell Brooks2, Philip Stainton3
1Centre for Applied Sport and Exercise Sciences, Faculty of Health and Wellbeing, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK. jksinclair@uclan.ac.uk.
Female athletes experience higher anterior cruciate ligament (ACL) forces and strains during hopping compared to males. This study investigated sex differences in ACL loading during athletic movements.
Area of Science:
- Biomechanics
- Sports Medicine
- Orthopedics
Background:
- Female athletes have a higher incidence of anterior cruciate ligament (ACL) injuries compared to males.
- The underlying biomechanical mechanisms contributing to this sex disparity are not fully understood.
Purpose of the Study:
- To investigate sex differences in anterior cruciate ligament (ACL) loading during cutting and hopping movements.
- To utilize a musculoskeletal simulation approach to analyze ACL forces and strains.
Main Methods:
- Fifteen male and fifteen female athletes performed 45° cut and one-legged hop movements.
- Three-dimensional motion capture and ground reaction force data were collected.
- A musculoskeletal model was used to extract lower extremity muscle forces, ACL forces, and ACL strains.
Main Results:
- Females exhibited significantly greater peak ACL forces and strains during the hop movement.
- Males showed a significantly larger soleus/gastrocnemius muscle activation ratio during both cut and hop movements.
- These findings suggest distinct biomechanical loading patterns between sexes during athletic tasks.
Conclusions:
- This study provides novel insights into sex-specific biomechanical differences during athletic movements.
- The results contribute to understanding the increased risk of ACL injuries in female athletes.
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