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Updated: Jan 31, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Structural Studies of Autophagy-Related Proteins
Melanie Schwarten1, Oliver H Weiergräber1, Dušan Petrović1,2
1Institute of Complex Systems ICS-6 (Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Abstract:
Information about the structure and dynamics of proteins is crucial for understanding their physiological functions as well as for the development of strategies to modulate these activities. In this chapter we will describe the work packages required to determine the three-dimensional structures of proteins involved in autophagy by using X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. Further we will provide instructions how to perform a molecular dynamics (MD) simulation using GABARAP as example protein.
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