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Updated: Jan 31, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent

Michał Antoszczak1

  • 1Department of Bioorganic Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61‒614 Poznań, Poland.

European Journal of Medicinal Chemistry
|January 6, 2019
PubMed

Insights

Salinomycin (SAL) effectively targets cancer stem cells (CSCs), a small tumor subpopulation responsible for cancer progression and relapse. This review explores SAL

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Tumors exhibit phenotypic heterogeneity, containing a small fraction of cancer stem cells (CSCs).
  • The cancer stem cell hypothesis links CSCs to tumor metastasis, progression, and recurrence.
  • Targeting CSCs is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To review the therapeutic potential of salinomycin (SAL) against cancer stem cells.
  • To explore SAL's efficacy across various cancer types and drug-resistant models.
  • To discuss the future role of SAL in cancer treatment strategies.

Main Methods:

  • Review of existing scientific literature on salinomycin and cancer stem cells.
  • Analysis of in vitro and in vivo studies demonstrating SAL's effects on CSCs.
  • Evaluation of SAL's activity against multi-drug resistant cancer cells.

Main Results:

  • Salinomycin (SAL) selectively reduces breast cancer stem cells in vitro and in vivo.
  • SAL exhibits activity against CSCs from diverse cancer origins.
  • SAL demonstrates efficacy against multi-drug resistant cancer cells and CSCs.

Conclusions:

  • Salinomycin shows significant promise as a therapeutic agent targeting cancer stem cells.
  • SAL's broad-spectrum activity and effectiveness against resistant cancers warrant further investigation.
  • SAL may play a key role in future cancer therapy strategies.
Keywords:
Cancer stem cellsMechanism of actionMulti-drug resistancePolyether ionophoresSalinomycinSensitizing effectsSynergyTargeted therapyToxicity

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