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Updated: Jan 31, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
Published on: January 10, 2017
Conical nanofluidic channel for selective quantitation of melamine in combination with β-cyclodextrin and a
Zhipeng Xie1, Jinlong Lei2, Mingfeng Yang2
1Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China; School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China.
Abstract:
Amine group-bearing small molecules tend to adsorb onto the nanochannel surfaces, which degrades the efficiency of nanochannel sensors. In this study, we utilized host-guest knowledge to eliminate the influence of excessive small molecules. In combination with single-walled carbon nanotubes (SWNTs), β-cyclodextrin (β-CD) provided an excellent sensing performance for the conical nanochannel coated with polyethyleneimine (PEI) and zirconium ion (Zr4+). By taking detection of melamine as a prototype, the as-prepared nanochannel could selectively detect melamine-elicited double-stranded DNA (dsDNA). Both excessive melamine and single-stranded DNA were removed via the addition of β-CD and SWNTs. The nanochannel sensing platform for the detection of melamine has a detection limit of as low as 4.3 nM with a suitable sensitivity, an excellent reproducibility and stability. Therefore, it is highly promising that a nanochannel sensor based on ion current rectification (ICR) can be used to detect other possible targets.
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