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SeqClone: sequential Monte Carlo based inference of tumor subclones

Oyetunji E Ogundijo1, Xiaodong Wang2

  • 1Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

BMC Bioinformatics
|January 7, 2019
PubMed
Summary

This study introduces SeqClone, a novel method for analyzing tumor genetic heterogeneity. SeqClone efficiently deconvolves variant allele fractions to identify subclonal genotypes and proportions, improving cancer prognosis and therapy design.

Keywords:
Bayesian modelIndian buffet processSequential Monte CarloTumor heterogeneity

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