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Down Syndrome and Postoperative Complications in Children Undergoing Intestinal Operations

Sarah B Cairo1, Lida I Zeinali2, Sara K Berkelhamer3

  • 1Department of Pediatric Surgery, John R. Oishei Children's Hospital, Buffalo, NY.

Journal of Pediatric Surgery
|January 7, 2019
PubMed

Insights

Pediatric patients with Down syndrome (DS) undergoing intestinal surgery do not experience higher medical or surgical complication rates. Contrary to adult data, these children show decreased inpatient mortality after intestinal operations compared to peers without DS.

Area of Science:

  • Pediatric Surgery
  • Genetics
  • Clinical Outcomes

Background:

  • Down syndrome (DS) is associated with increased medical risks in adults.
  • Limited data exists on postoperative complications in pediatric patients with DS undergoing intestinal operations.
  • Understanding these risks is crucial for optimizing surgical care.

Purpose of the Study:

  • To evaluate the association between Down syndrome (DS) and postoperative medical and surgical complications.
  • To assess inpatient postoperative mortality in pediatric patients undergoing intestinal operations.
  • To compare outcomes between pediatric patients with and without DS.

Main Methods:

  • Retrospective comparative study using the 2012 Kids' Inpatient Database.
  • Compared 444 pediatric patients with DS to a cohort without DS undergoing intestinal operations.
  • Inverse probability weighting and adverse treatment effect analysis were employed.

Main Results:

  • Unadjusted analysis showed lower medical complication rates in patients with DS.
  • Surgical complication rates were similar between groups.
  • After inverse probability weighting, no significant difference in medical or surgical complications was found, but mortality was significantly decreased in patients with DS.

Conclusions:

  • Pediatric patients with DS do not have higher medical or surgical complication rates after intestinal operations.
  • These patients exhibit lower postoperative inpatient mortality compared to those without DS.
  • The underlying mechanisms for these observed outcomes in DS patients remain unclear.
Abstract

Keywords:
Down syndromePediatric surgeryPostoperative complicationsTrisomy 21

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