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Updated: Jan 31, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control
Sylvia Varland1, Joël Vandekerckhove2, Adrian Drazic3
1Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5020 Bergen, Norway; Department of Biological Sciences, University of Bergen, Thormøhlensgate 53 A, N-5020 Bergen, Norway; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Abstract:
Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities, including muscle contraction, maintenance of cell integrity, and motility, as well as transcriptional regulation. Besides interacting with various actin-binding proteins (ABPs), proper actin function is regulated by post-translational modifications (PTMs), such as acetylation, arginylation, oxidation, and others. Here, we explain how actin PTMs can contribute to filament formation and stability, and may have additional actin regulatory functions, which potentially contribute to disease development.
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