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Related Experiment Video

Updated: Jan 31, 2026

fMRI Validation of fNIRS Measurements During a Naturalistic Task

fMRI Validation of fNIRS Measurements During a Naturalistic Task

Published on: June 15, 2015

Awake and behaving mouse fMRI during Go/No-Go task.

Zhe Han¹, Wenjing Chen², Xifan Chen²

¹Institute of Neuroscience, CAS Center for Excellence in Brain Sciences and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, China.

|January 7, 2019

Summary

Researchers developed a novel functional magnetic resonance imaging (fMRI) method for awake, behaving mice. This technique allows whole-brain imaging during olfactory tasks, offering new insights into neural mechanisms of behavior.

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Area of Science:

Neuroscience
Functional Neuroimaging
Animal Models

Background:

Functional magnetic resonance imaging (fMRI) is crucial for studying brain activity.
Anesthesia in rodent fMRI limits behavioral relevance and scope.
Previous attempts to image awake rodents have not achieved true behavioral paradigms.

Purpose of the Study:

To develop a novel fMRI paradigm for imaging awake and behaving mice.
To enable functional brain imaging during a specific behavioral task.
To overcome limitations of anesthesia in rodent fMRI studies.

Main Methods:

Developed a novel fMRI paradigm for awake, behaving mice.
Utilized high-resolution imaging at 9.4T with a cryogenic coil.
Implemented an olfaction-based go/no-go task to elicit specific brain responses.

Main Results:

Achieved high-resolution fMRI with minimal motion and image distortion in awake mice.
Revealed distributed whole-brain spatiotemporal activity patterns.
Demonstrated distinct brain activity profiles for 'go' versus 'no-go' trials.

Conclusions:

Successfully demonstrated the feasibility of functional imaging of olfactory behavior in awake mice.
The developed fMRI paradigm allows for studying neural mechanisms underlying behavior at a whole-brain level.
This advancement opens new avenues for understanding brain function in naturalistic behavioral states.