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Updated: Jan 31, 2026

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
Published on: August 16, 2018
CXCR4 Antagonism to Treat Delayed Fracture Healing
Richard Meeson1,2, Anita Sanghani-Keri1, Melanie Coathup1,3
1Division of Surgery, Institute of Orthopaedics and Musculoskeletal Science, University College London, London, United Kingdom.
Impact Statement:
Currently ∼10% of fractures progress to delayed or nonunion with significant morbidity and economic impact. Endogenous mobilization of stem cells by pharmacological antagonism of their homing and migration receptor CXCR4 with AMD3100 experimentally reduced delayed union development. Endogenous mobilization may, therefore, translate as a low risk means to boost healing and could potentially be given as a prophylaxis to patients with fractures at risk of delayed healing or nonunion. These patients may include fragility fractures, comminuted tibial fractures, or when treating established nonunions. This approach could have promise for other conditions that may benefit from stem cell treatments.
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