A giant trichoblastic carcinoma

Area of Science:

• Dermatopathology
• Surgical Oncology
• Oncology

Background:

• Trichoblastic carcinoma is a rare malignancy arising from trichoblastoma.
• It often presents as a recurrence and can be challenging to diagnose.
• Giant presentations, though exceptionally rare, have been documented.

Purpose of the Study:

• To report a rare case of giant trichoblastic carcinoma.
• To detail the diagnostic and surgical management of this rare skin adnexal carcinoma.
• To emphasize the importance of histopathological features for diagnosis.

Main Methods:

• A 25-year-old male patient with a recurrent nuchal trichoblastoma was evaluated.
• Preoperative imaging (MRI) assessed tumor extent and muscle infiltration.
• Wide surgical excision and free anterolateral thigh flap reconstruction were performed.

Main Results:

• Histopathological examination confirmed trichoblastic carcinoma originating from hair follicles.
• The patient achieved a 5-year disease-free status with no palpable mass.
• Follow-up imaging (PET-CT) showed no signs of recurrence.

Conclusions:

• Trichoblastic carcinoma is rare and diagnosis can be difficult.
• Key histopathological findings include atypical basaloid keratinocytes and hypercellular stroma.
• Successful surgical management and reconstruction can lead to long-term remission.