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Rapid Encapsulation of Reconstituted Cytoskeleton Inside Giant Unilamellar Vesicles

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Published on: November 10, 2021

A giant trichoblastic carcinoma.

Joon Seok Lee¹, Joon Hyun Kwon¹, Gyu Sik Jung¹

¹Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Archives of Craniofacial Surgery

|January 8, 2019

Summary

Trichoblastic carcinoma, a rare hair follicle cancer, was successfully treated in a young man with a large, recurrent neck tumor. Surgical removal and reconstruction led to a 5-year disease-free survival, highlighting effective management strategies.

Keywords:

Cutaneous adnexal tumors Free anterolateral thigh flap Trichoblastic carcinoma

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Area of Science:

Dermatopathology
Surgical Oncology
Oncology

Background:

Trichoblastic carcinoma is a rare malignancy arising from trichoblastoma.
It often presents as a recurrence and can be challenging to diagnose.
Giant presentations, though exceptionally rare, have been documented.

Purpose of the Study:

To report a rare case of giant trichoblastic carcinoma.
To detail the diagnostic and surgical management of this rare skin adnexal carcinoma.
To emphasize the importance of histopathological features for diagnosis.

Main Methods:

A 25-year-old male patient with a recurrent nuchal trichoblastoma was evaluated.
Preoperative imaging (MRI) assessed tumor extent and muscle infiltration.
Wide surgical excision and free anterolateral thigh flap reconstruction were performed.

Main Results:

Histopathological examination confirmed trichoblastic carcinoma originating from hair follicles.
The patient achieved a 5-year disease-free status with no palpable mass.
Follow-up imaging (PET-CT) showed no signs of recurrence.

Conclusions:

Trichoblastic carcinoma is rare and diagnosis can be difficult.
Key histopathological findings include atypical basaloid keratinocytes and hypercellular stroma.
Successful surgical management and reconstruction can lead to long-term remission.