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Aspartame intolerance.

M M Garriga1, D D Metcalfe

  • 1Mast Cell Physiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

Annals of Allergy
|December 1, 1988
PubMed
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Aspartame, an artificial sweetener, is approved for many foods but requires labeling for individuals with phenylketonuria (PKU). It is considered safe and does not pose long-term cancer risks.

Area of Science:

  • Food Science
  • Toxicology
  • Regulatory Science

Background:

  • Aspartame is a widely used artificial sweetener, marketed as Nutrasweet.
  • It is composed of two amino acids and is significantly sweeter than sugar.
  • The Food and Drug Administration (FDA) approved its use in various food products starting in 1981.

Purpose of the Study:

  • To review the safety and regulatory status of aspartame.
  • To inform consumers about aspartame's composition and approved uses.
  • To address concerns regarding potential adverse reactions and long-term health risks.

Main Methods:

  • Review of FDA approvals and regulations.
  • Analysis of aspartame's chemical composition and breakdown products.
  • Examination of reported adverse events and scientific studies on toxicity.

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Main Results:

  • Aspartame is approved for a wide range of food and beverage applications.
  • It requires specific labeling for individuals with phenylketonuria (PKU) due to phenylalanine content.
  • Aspartame is deemed free of long-term cancer risks and its breakdown products are considered safe in amounts typically consumed.

Conclusions:

  • Aspartame is a safe food additive when consumed as directed.
  • Regulatory bodies like the FDA monitor its safety through adverse event reporting.
  • While generally safe, its stability and breakdown products are important considerations for use in food processing.