Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

First Pass Effect01:12

First Pass Effect

9.3K
Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
9.3K
What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Single-pass Transmembrane Proteins01:25

Single-pass Transmembrane Proteins

6.6K
Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
6.6K
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

8.1K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.1K
Insertion of Single-pass Transmembrane Proteins in the RER01:26

Insertion of Single-pass Transmembrane Proteins in the RER

18.1K
Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
18.1K
Insertion of Multi-pass Transmembrane Proteins in the RER01:29

Insertion of Multi-pass Transmembrane Proteins in the RER

18.3K
The rough ER membrane synthesizes, assembles, and embeds transmembrane proteins in diverse topologies. These proteins function as transporters or channels and can remain in the ER membrane or are sent to the Golgi complex, lysosome, and cell membrane.
The multipass transmembrane proteins are the type IV integral membrane proteins with multiple topogenic sequences determining their spatial arrangement in the ER membrane. Nearly all multipass proteins lack a cleavable signal sequence and use...
18.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Framework with Transformer-Based Model for Cerebrovascular Stenosis Detection in Magnetic Resonance Angiography.

Journal of imaging informatics in medicine·2026
Same author

Artificial Intelligence-Assisted Clinical Decision Support System in Telemedical Wound Care: A Randomized Controlled Trial.

Annals of plastic surgery·2026
Same author

A Timeseries-based Multimodal Deep Learning Approach for Lung Nodule Growth Prediction.

Journal of imaging informatics in medicine·2025
Same author

Application of deep learning in wound size measurement using fingernail as the reference.

BMC medical informatics and decision making·2024
Same author

The effects of topical anesthesia on outcomes and glucose control in diabetic patients treated with split-thickness skin graft surgery.

Journal of the Chinese Medical Association : JCMA·2022
Same author

Decision support system for the differentiation of schizophrenia and mood disorders using multiple deep learning models on wearable devices data.

Health informatics journal·2022

Related Experiment Video

Updated: Jan 31, 2026

Analyzing Spatial Learning and Prosocial Behavior in Mice Using the Barnes Maze and Damsel-in-Distress Paradigms
08:00

Analyzing Spatial Learning and Prosocial Behavior in Mice Using the Barnes Maze and Damsel-in-Distress Paradigms

Published on: November 17, 2018

15.1K

Who will pass? Analyzing learner behaviors in MOOCs.

Shu-Fen Tseng1, Yen-Wei Tsao2, Liang-Chih Yu1

  • 11Department of Information Management and Innovation Center for Big Data and Digital Convergence, Yuan Ze University, 135 Yuan-Tong Road, Chung-Li District Tao-Yuan City, Taiwan.

Research and Practice in Technology Enhanced Learning
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

Active participation in Massive Open Online Courses (MOOCs) correlates with better learning outcomes. Early instructor intervention is crucial for student retention in online learning environments.

Keywords:
Learning analyticsLearning behaviorLearning engagementMOOCs

More Related Videos

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K
Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST

Published on: April 23, 2015

10.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Analyzing Spatial Learning and Prosocial Behavior in Mice Using the Barnes Maze and Damsel-in-Distress Paradigms
08:00

Analyzing Spatial Learning and Prosocial Behavior in Mice Using the Barnes Maze and Damsel-in-Distress Paradigms

Published on: November 17, 2018

15.1K
Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K
Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST

Published on: April 23, 2015

10.4K

Area of Science:

  • Education
  • Computer-Assisted Instruction
  • E-learning

Background:

  • Massive Open Online Courses (MOOCs) are increasingly popular educational tools.
  • However, the measurable learning benefits and student behaviors within MOOCs require further investigation.

Purpose of the Study:

  • To classify student learning behaviors in MOOCs.
  • To examine the relationship between different learner types and their academic outcomes.
  • To identify critical factors for student retention and engagement in MOOCs.

Main Methods:

  • Utilized Ward's hierarchical and k-means clustering methods to analyze behavioral data from 1489 students across three MOOCs.
  • Classified learners into three distinct types: active, passive, and bystander.

Main Results:

  • Active learners, characterized by timely assignment submission and frequent video engagement, achieved higher completion rates and grades.
  • Participation in online discussion forums was linked to improved course passing rates and scores.
  • The initial two weeks of a MOOC are critical for student retention.

Conclusions:

  • Learner behavior significantly impacts MOOC outcomes; active engagement is key.
  • Early identification of at-risk students and timely instructor feedback on discussion forums can enhance engagement and prevent dropouts.
  • Course design and discussion forum features should prioritize peer interaction and timely support.