Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.5K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.1K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.1K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

5.4K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.4K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

3.8K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.8K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.8K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.8K
Positive Regulator Molecules01:45

Positive Regulator Molecules

136.2K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison Between Titanium and Polyether Ether Ketone Cranioplasty Based on Preoperative Imaging Indicators and Analysis of Risk Factors for Postoperative Adverse Events.

World neurosurgery·2026
Same author

Systematic analyses to explore kinase gene set-based signature in glioma, in which WEE1 contributes to tumor progression.

Discover oncology·2026
Same author

Sequential manifestation of Kaposi's sarcoma and diffuse large B-cell lymphoma in the context of HIV infection: Case report of a rare presentation.

Medicine·2026
Same author

Focal Adhesion Related Gene Signature for Glioma: The Pivotal Role of RAP1B in Disease Progression.

Current medicinal chemistry·2026
Same author

High-power dual-channel chamber for high-frequency magnetic neuromodulation.

Journal of neural engineering·2026
Same author

Cytosine base editing of LPA in transgenic mice averts large deletions.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Related Experiment Video

Updated: Jan 31, 2026

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
11:14

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

Published on: January 6, 2017

8.4K

Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis.

Jing Liu1, Youichiro Wada2, Mari Katsura2

  • 1Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Theranostics
|January 8, 2019
PubMed
Summary

Rho-associated coiled-coil kinase (ROCK) is crucial for angiogenesis, the formation of new blood vessels. Targeting ROCK signaling offers a promising therapeutic strategy for angiogenesis-related diseases like cancer and diabetes.

Keywords:
Rho-associated coiled-coil kinase (ROCK)angiogenesisendothelial cellmicroenvironmenttherapeutic target

More Related Videos

How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression
07:00

How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

Published on: January 23, 2017

24.9K
Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

3.3K

Related Experiment Videos

Last Updated: Jan 31, 2026

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
11:14

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

Published on: January 6, 2017

8.4K
How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression
07:00

How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

Published on: January 23, 2017

24.9K
Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

3.3K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Rho-associated coiled-coil kinase (ROCK) is a key regulator of cellular functions.
  • Angiogenesis is vital for disease development, including cancer, diabetes, and rheumatoid arthritis.
  • ROCK signaling plays a critical role in angiogenesis.

Purpose of the Study:

  • To review the role of ROCK signaling in endothelial cell functions.
  • To explore ROCK's involvement in the pro-angiogenic microenvironment.
  • To discuss the therapeutic potential of ROCK inhibitors in angiogenesis-related diseases.

Main Methods:

  • Literature review of recent advances in ROCK signaling and angiogenesis.
  • Analysis of ROCK's regulation of endothelial cell permeability, migration, proliferation, and tubulogenesis.
  • Examination of ROCK's function in non-endothelial cells within the microenvironment.

Main Results:

  • ROCK signaling is a versatile regulator of endothelial cell behavior crucial for angiogenesis.
  • ROCK influences the pro-angiogenic microenvironment through its actions on non-ECs.
  • ROCK inhibitors demonstrate therapeutic potential for treating angiogenesis-related pathologies.

Conclusions:

  • ROCK is a significant target for therapeutic intervention in angiogenesis-related diseases.
  • Understanding ROCK signaling pathways is essential for developing novel treatments.
  • ROCK inhibitors hold promise for managing conditions driven by aberrant angiogenesis.