Related Experiment Video

Updated: Jan 31, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

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Targeted nanoparticles for multimodal imaging of the receptor for advanced glycation end-products

Lindsey R Drake1, Peter J H Scott1

  • 1Departments of Radiology and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Theranostics
|January 8, 2019
PubMed

Insights

A new multimodal nanoparticle imaging agent targets the receptor for advanced glycation end-products (RAGE). This tool aids in quantifying RAGE levels in vivo, supporting RAGE-targeted therapies and inhibitor development.

Area of Science:

  • Biomedical imaging
  • Nanotechnology
  • Molecular biology

Background:

  • Receptor for advanced glycation end-products (RAGE) is linked to diseases like cancer, diabetes, and neurodegeneration.
  • RAGE inhibitors are under investigation as novel therapeutic strategies.
  • Accurate in vivo quantification of RAGE is crucial for biomarker validation and drug development.

Discussion:

  • This editorial reviews a novel multimodal nanoparticle-based imaging agent designed to target RAGE.
  • The agent facilitates in vivo RAGE quantification, addressing a critical unmet need in RAGE-related disease research.
  • This development supports the validation of RAGE as a therapeutic target and aids in the advancement of RAGE inhibitor therapies.

Key Insights:

  • A multimodal nanoparticle imaging agent for RAGE has been developed.
  • This agent enables accurate in vivo quantification of RAGE levels.
  • It serves as a valuable tool for RAGE biomarker validation and RAGE inhibitor development.

Outlook:

  • The developed imaging agent holds promise for advancing RAGE-targeted therapies.
  • It can accelerate the clinical translation of RAGE inhibitors.
  • Further research may explore its application in various RAGE-associated pathologies.
Keywords:
multimodal imagingpositron emission tomography.receptor for advanced glycation end-products

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