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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
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Current Treatment for Myositis.

Simone Barsotti1,2, Ingrid E Lundberg3

  • 11Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Current Treatment Options in Rheumatology
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

High-dose glucocorticoids are the primary treatment for myositis. Combining immunosuppressants with exercise improves outcomes and reduces side effects in patients with idiopathic inflammatory myopathies.

Keywords:
Clinical phenotypeIdiopathic inflammatory myopathiesImmunosuppressantMyositisTreatment

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Area of Science:

  • Rheumatology
  • Immunology
  • Neurology

Background:

  • Idiopathic inflammatory myopathies (myositis) are rare autoimmune diseases.
  • Treatment options for myositis are limited, with few controlled trials available.
  • This review focuses on myositis, excluding inclusion body myositis.

Purpose of the Study:

  • To provide an updated overview of current treatment modalities for myositis.
  • To summarize findings from controlled trials, open-label studies, case series, and case reports.
  • To inform clinical practice and future research directions in myositis management.

Main Methods:

  • Comprehensive literature survey of therapies used in myositis.
  • Inclusion of data from various study designs, including controlled trials, open-label trials, case series, and case reports.
  • Focus on treatment modalities excluding inclusion body myositis.

Main Results:

  • High-dose glucocorticoids remain the first-line therapy for myositis.
  • Combination therapy with immunosuppressive agents is recommended in the early disease phase.
  • Evidence supports combining pharmacological treatment with supervised exercise for improved outcomes.
  • Rituximab shows potential efficacy in specific patient subgroups with myositis-specific autoantibodies.

Conclusions:

  • Combination therapy (immunosuppressants and exercise) is recommended to manage myositis activity and enhance muscle function.
  • Subgrouping patients based on clinical and serological profiles may identify biomarkers for targeted therapies.
  • Future trials should consider patient stratification to optimize treatment response to immunosuppressive and biologic agents.