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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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HOXA10 expression profiling in prostate cancer.

Yuji Hatanaka1, Marco A de Velasco1,2, Takashi Oki1

  • 1Department of Urology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

The Prostate
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

High HOXA10 expression in prostate cancer (PCa) correlates with better outcomes and suggests a tumor-suppressive role. This finding was observed in both human and mouse studies, indicating HOXA10

Keywords:
HOXA10biomarkerprostate cancerradical prostatectomy

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • HOX genes are crucial transcription factors regulating tissue development and homeostasis.
  • Aberrant HOX gene expression is implicated in various human cancers, with roles in both tumor promotion and suppression.
  • HOXA10, a key gene in prostate development, exhibits altered expression in prostate cancer (PCa).

Purpose of the Study:

  • To investigate the expression patterns of HOXA10 in human and mouse prostate cancer.
  • To determine the clinical significance of HOXA10 expression in relation to clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP).

Main Methods:

  • A meta-analysis of HOXA10 mRNA expression across public datasets.
  • Immunohistochemistry (IHC) to assess HOXA10 protein expression in human RP tissues.
  • Correlation analysis of HOXA10 expression with clinicopathological variables and BCR using Kaplan-Meier methods.
  • Examination of HOXA10 expression in a mouse model of Pten-null PCa.

Main Results:

  • Meta-analysis revealed dysregulated HOXA10 expression in human PCa.
  • IHC showed inverse correlations between HOXA10 expression and Gleason grade, score, and pathological stage (P < 0.01).
  • Low HOXA10 expression was linked to a higher risk of BCR (OR, 3.54; P = 0.049), while high expression correlated with longer BCR-free survival (P = 0.045).
  • HOXA10 was not an independent predictor of BCR (OR, 1.52; P = 0.52).
  • Mouse prostate tumors mirrored human HOXA10 expression patterns.

Conclusions:

  • HOXA10 expression is inversely associated with tumor differentiation in PCa.
  • Elevated HOXA10 expression correlates with improved BCR-free survival.
  • Evidence from human and mouse studies suggests a tumor-suppressive function for HOXA10 in prostate cancer.